Welcome to the website of the Oklahoma Center of Biomedical Research Excellence in Structural Biology (OCSB). This NIH-funded center supports research groups on the OU-Norman and OUHSC campuses that utilize a structural approach to study important biological macromolecules, in particular, proteins or nucleic acids that are promising targets for rationale drug design. Structural biology lies at the intersection of many different areas of biological sciences and thus has the potential of impacting numerous biomedically important fields. This award will provide significant resources for investigators at OU and through-out the State to pursue structure-based biomedical studies.
The overall objectives of the OCSB are to:
1) Further the research activities and career development of junior investigators through senior mentorship and strengthening of research infrastructure.
2) Create state-wide core facilities in macromolecular X-ray crystallography, high throughput crystallization, and protein expression/purification, which will provide users access to shared major instrumentation, staff support and research training.
3) Promote structural biology in the State of Oklahoma through COBRE activities such as annual symposia, workshops, a seed grant program and core research facilities.
Collectively, these objectives are expected to increase the pace, competitiveness and success rate of structural biology research groups in Oklahoma as they seek major independent external grant support.
Ann West, Program Director
Gillian Air, Associate Program Director
Funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health (Award No. P20GM103640).